Tumor Suppressor Protein p53 Complex Formation and Stabilization of the Apoptosis in J774 Macrophages through The Bacterial Redox Protein Azurin Induces
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Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin.
The tumor suppressor protein p53 is known to induce either apoptosis or growth arrest depending on cellular background. We have previously reported that a bacterial redox protein azurin induces apoptosis in J774 cell line-derived macrophages whereas a site-directed mutant M44KM64E azurin shows very little cytotoxicity and fails to induce apoptosis in J774 cells. We now report that purified M44K...
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تاریخ انتشار 2002